Volume I, the first of five volumes of hearings of the HSCA, consists of transcripts of the HSCA proceedings of September 6 through 8, 1978.

The opening day of hearings got underway with a statement by Representative Richardson Preyer, followed by the testimony of Mr. and Mrs. John Connally. The Governor of Texas in 1963, John Connally had been involved in preparations for the fated motorcade trip. He was also wounded in the shooting in Dealey Plaza.

The second day of testimony related to the medical evidence and analysis in the case. Much of this was presented by Dr. Michael Baden, head of the HSCA's nine-member Medical Panel. This day also saw the testimony of Capt. James J. Humes, the lead prosector at the autopsy of President Kennedy. Humes publicly retracted the autopsy report's placement of the fatal entry wound, which the Medical Panel determined was 4 inches away from the originally-noted spot. In 1992 for the Journal of the American Medical Association, and again in 1996 before the Assassinations Record Review Board, Humes retracted this retraction. The final medical witness on Sept. 7 was Dr. Cyril Wecht, the lone dissenter on the Medical Panel.

The third day, Sept. 8, continued the medical testimony and presented the findings of the Firearms Panel, concerned with the ballistics evidence. The final witness was Dr. Vincent Guinn, who performed Neutron Activation Analysis (NAA) on bullet fragments to determine whether they came from the same bullet.